Understanding how cell changes affect organ function
Chemical toolbox for multiscale, integrative imaging: Connecting cellular gene expression to organ-scale phenotype
This study is looking at how tiny changes in our cells can affect how our organs work, using cool tools to see what's happening inside, and it could help us understand more about different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10929353 on NIH RePORTER |
What this research studies
This research investigates how changes at the cellular level can lead to dysfunction in organs. By using advanced techniques like single-cell sequencing and CRISPR, the team aims to connect genetic alterations in individual cells to the overall health and function of organs. The approach combines various imaging methods to visualize and analyze cellular interactions and structures within tissues. This comprehensive understanding could help in identifying the mechanisms behind diseases and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic abnormalities or diseases that affect organ function.
Not a fit: Patients with isolated or non-genetic conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into disease mechanisms and potential therapeutic targets for various conditions.
How similar studies have performed: Other research has shown promising results using similar integrative approaches to connect cellular and organ-level phenomena, indicating potential for success in this area.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Han, Hee-Sun — University of Illinois at Urbana-Champaign
- Study coordinator: Han, Hee-Sun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.