Understanding how cell changes affect aging and stress
Role of methylation-dependent pathways in aging and stress
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11112488
This research explores how a key molecule in our cells, called SAM, helps manage stress and the aging process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11112488 on ClinicalTrials.gov |
What this research studies
Our bodies rely on metabolic cycles to build and power our cells, but these cycles also create signals that influence many bodily functions, including aging. One important signal is a molecule called S-adenosylmethionine (SAM), which helps control how our genes react to stress, a key factor in the aging process. We've found that different ways our bodies make SAM have distinct effects. By learning more about how SAM is produced and regulated, we hope to gain new insights into how our bodies respond to stress and age.
Who could benefit from this research
Good fit: This foundational research does not currently involve patient participation, but future studies building on this work might seek adults interested in understanding the biological processes of aging and stress.
Not a fit: Patients seeking immediate clinical treatments for specific conditions would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for promoting healthy aging and improving our body's ability to cope with stress.
How similar studies have performed: While the role of SAM in biological processes is known, this research explores novel mechanisms regulating its local production, offering a fresh perspective.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALKER, AMY KAROL — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: WALKER, AMY KAROL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.