Understanding how cell aging affects osteoarthritis differently in men and women
Official title: Cell Senescence Regulating Osteoarthritis Progression: Sex-dependent Mechanisms
Funded at Rhode Island Hospital · NIH-10986987 · Data updated 2026-11-12
This study is looking at how aging cells affect osteoarthritis, especially why women might experience worse symptoms than men, to find new ways to help treat the condition better for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | January 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $549,266 |
| NIH project number | 5R01AG080141-03 |
| Project ID | NIH-10986987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly women, who are experiencing symptoms of osteoarthritis.
✕Less likely to help
Patients who are younger or do not have osteoarthritis may not receive any benefit from this research.
What this research studies
This research investigates the role of cell senescence in the progression of osteoarthritis (OA), particularly focusing on how these mechanisms differ between sexes. It aims to uncover the molecular processes that lead to more severe OA in aging women compared to men. By studying the activation of specific markers associated with cell aging and their impact on joint health, the research seeks to identify potential therapeutic targets. Patients may benefit from insights that could lead to more effective treatments tailored to their sex and age.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of osteoarthritis progression in women, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding sex differences in disease progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Chen, Qian — Rhode Island Hospital
- Study coordinator: Chen, Qian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.