Understanding how cell adhesion molecules affect retinal development
Mechanisms of Cell Adhesion Molecule Function in Retinal Development
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10885117
This study is looking at how certain proteins called cell adhesion molecules help the retina develop properly, which is important for good vision, and it's using mice to learn more about how these proteins affect the health of nerve cells and their connections, with the hope of understanding eye-related disorders better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10885117 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cell adhesion molecules (CAMs) in the development of the retina, which is crucial for visual processing. Using a mouse model, the study focuses on a specific group of CAMs known as gamma-protocadherins, which are essential for the survival of neurons and the formation of neural circuits. The researchers employ advanced techniques like CRISPR/Cas9 to create various mouse mutants to explore how different isoforms of these molecules contribute to neuronal health and circuit formation. By understanding these mechanisms, the research aims to shed light on neurodevelopmental disorders linked to CAM mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with visual processing issues or related conditions.
Not a fit: Patients with neurodevelopmental disorders unrelated to visual processing or those without any genetic mutations affecting CAMs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treatments for neurodevelopmental disorders that affect vision and cognition.
How similar studies have performed: Previous research has shown promising results in understanding the role of CAMs in neural development, indicating that this approach has potential for significant findings.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARRETT, ANDREW — WAYNE STATE UNIVERSITY
- Study coordinator: GARRETT, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.