Understanding how Cdk5 and p35 affect natural killer cell function in cancer
Investigating the role of Cdk5 and p35 in natural killer cell cytotoxicity
This study is looking at how certain proteins affect the ability of natural killer (NK) cells to fight cancer, especially when there are high levels of a substance called TGF-β that can weaken the immune system, with the hope of finding better treatments for cancers like acute lymphoblastic leukemia.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10919174 on NIH RePORTER |
What this research studies
This research investigates the role of Cdk5 and p35 proteins in natural killer (NK) cells, which are crucial for targeting and destroying cancer cells. The study aims to understand how these proteins influence NK cell activity, particularly in the context of elevated TGF-β levels that can impair immune responses in cancer patients. By exploring the signaling pathways involved, the research seeks to identify potential strategies to enhance NK cell effectiveness in cancer immunotherapy. Patients may benefit from insights that could lead to improved treatments for cancers like acute lymphoblastic leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute lymphoblastic leukemia or other cancers where NK cell function is critical.
Not a fit: Patients with non-cancerous conditions or those whose cancer does not involve NK cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to fight cancer.
How similar studies have performed: Previous research has shown promising results in enhancing NK cell activity through various immunotherapy approaches, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wong, Derek Perseus — Case Western Reserve University
- Study coordinator: Wong, Derek Perseus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.