Understanding how Cdc42 affects cell division and tissue development
Official title: Cdc42-mediated regulation of spindle positioning in a vertebrate model
Funded at University of Wisconsin-Madison · NIH-11003286 · Data updated 2026-11-12
This study is looking at how a protein called Cdc42 helps control where the cell's dividing machinery is placed, which is important for healthy tissue growth and preventing issues like genetic defects and tumors.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | January 12, 2024 |
| Project end | January 11, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32GM150267-02 |
| Project ID | NIH-11003286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cancer or developmental disorders linked to cell division abnormalities.
✕Less likely to help
Patients with stable, non-cancerous conditions unrelated to cell division or tissue morphogenesis may not benefit from this research.
What this research studies
This research investigates the role of Cdc42 in regulating the positioning of the mitotic spindle during cell division, which is crucial for proper tissue development and cell fate determination. By studying vertebrate models, the research aims to uncover how misplacement of the spindle can lead to genetic defects and tumor development. The approach involves examining the interactions between Cdc42 and various cellular components that influence spindle orientation and positioning. This could provide insights into the fundamental processes of cell division and its implications for cancer biology.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers related to cell division errors.
How similar studies have gone: Previous studies have shown that understanding the mechanisms of spindle positioning can lead to significant advancements in cancer treatment, indicating that this research builds on established findings.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Sepaniac, Leslie a — University of Wisconsin-Madison
- Study coordinator: Sepaniac, Leslie a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.