Understanding how CD53 affects B cell movement and function
Defining the partner interaction network of the tetraspanin CD53 in regulating B cell trafficking
This study is looking at a protein called CD53 to see how it helps B cells, which are important for our immune system, move around and do their job, and it could help us understand how our immune responses work and what might go wrong in certain diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10854907 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called CD53 in regulating the movement and function of B cells, which are crucial for the immune response. The study aims to identify the network of interactions that CD53 has with other proteins to understand how it influences B cell behavior, including their development and ability to produce antibodies. By examining the structure of CD53 and its interactions, the research seeks to uncover the molecular mechanisms that govern B cell trafficking and adhesion. This could provide insights into how immune responses are coordinated and how they may be disrupted in diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with B cell-related disorders, such as B cell leukemia or other immune system dysfunctions.
Not a fit: Patients with conditions unrelated to B cell function or those who do not have any immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients with immune deficiencies or certain cancers.
How similar studies have performed: Other research has shown promising results in understanding protein interactions in immune cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Schuettpelz, Laura G. — Washington University
- Study coordinator: Schuettpelz, Laura G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.