Understanding how CD40L helps the immune system fight gut infections
The role of CD40L in resistance to enteric infection
This study is looking at how a molecule called CD40L helps the immune system fight off gut infections caused by a parasite, and it's aimed at finding new ways to boost immune responses for people dealing with these types of infections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11082285 on NIH RePORTER |
What this research studies
This research investigates the role of a molecule called CD40L in helping the immune system combat infections in the gut, specifically those caused by the parasite Cryptosporidium. Using a unique mouse model, the study examines how CD40L influences T cell responses and interacts with other cells to promote resistance to infection. The researchers aim to uncover the mechanisms behind CD40L's protective effects, which could lead to new strategies for enhancing immune responses in patients. By analyzing these interactions, the research seeks to provide insights into improving treatments for enteric infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems or those at risk for enteric infections.
Not a fit: Patients with no history of enteric infections or those with fully functional immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against gut infections, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hunter, Christopher a — University of Pennsylvania
- Study coordinator: Hunter, Christopher a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.