Understanding how CD4+ T cells protect the lungs from infections
Official title: CD4+ T cell Immunity in the Respiratory Tract
Funded at Tulane University of Louisiana · NIH-11036966 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs help protect against pneumonia, which can be very serious, especially for kids and older adults, by examining samples from mice and primates to learn what these cells need to survive and fight infections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | June 5, 2025 |
| Project end | May 31, 2032 |
| Funding year | 2025 |
| Award (this year) | $1,063,324 |
| NIH project number | 1R35HL177381-01 |
| Project ID | NIH-11036966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults who are at risk for pneumonia or have a history of respiratory infections.
✕Less likely to help
Patients with non-respiratory conditions or those who do not have a history of pneumonia may not benefit from this research.
What this research studies
This research investigates the role of CD4+ T cells in the respiratory tract, focusing on how these immune cells help defend against pneumonia, a leading cause of death in children and adults. The study will analyze lung and nasal tissue samples from mice and primates to understand the metabolic needs of these immune cells and whether exposure to antigens is necessary for their long-term survival. By exploring the interactions between T cells and lung fibroblasts, the research aims to uncover mechanisms that could enhance pulmonary defenses against infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating pneumonia, potentially saving lives and reducing illness in vulnerable populations.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in the lungs, indicating that this approach could yield valuable insights.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Kolls, Jay K — Tulane University of Louisiana
- Study coordinator: Kolls, Jay K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.