Understanding how CD4 T cell dysfunction affects brain infections from toxoplasmosis
CD4 dysfunction and cerebral toxoplasmosis
['FUNDING_R01'] · GEORGE WASHINGTON UNIVERSITY · NIH-11088764
This study is looking at how certain immune cells, called CD4 T cells, can help prevent a serious brain infection from coming back in people with weakened immune systems, and it aims to find ways to make these cells work better to keep you safe from toxoplasmosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11088764 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CD4 T cells in the reactivation of latent toxoplasmosis, particularly in immunocompromised individuals. It explores how the dysfunction of these cells can lead to severe brain infections known as toxoplasmic encephalitis. By using mouse models, the study aims to identify mechanisms that restore CD8 T cell functionality through the treatment of exhausted CD4 T cells. The ultimate goal is to develop strategies that can prevent the reactivation of this dangerous infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals, particularly those living with HIV/AIDS or other conditions that affect their immune system.
Not a fit: Patients who are not immunocompromised or do not have a history of latent toxoplasmosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune responses in patients with latent toxoplasmosis, potentially preventing life-threatening brain infections.
How similar studies have performed: Previous research has shown promising results in restoring T cell functionality in similar contexts, indicating that this approach may be effective.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGE WASHINGTON UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHAN, IMTIAZ AHMED — GEORGE WASHINGTON UNIVERSITY
- Study coordinator: KHAN, IMTIAZ AHMED
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Cancers