Understanding how CD38 affects chronic lymphocytic leukemia
Therapeutic implication of CD38 in CLL
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-10683157
This study is looking at a protein called CD38 in people with chronic lymphocytic leukemia (CLL) to see how it affects the disease and if new treatments that target this protein can help improve care for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10683157 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CD38, a protein found on blood cells, in chronic lymphocytic leukemia (CLL), a type of blood cancer. The study aims to understand how increased levels of CD38 contribute to the severity of CLL and whether targeting this protein with specific therapies can improve patient outcomes. By using newly developed agents that inhibit CD38, researchers hope to explore their effects on CLL biology and potentially enhance treatment options for patients. This research could lead to a better understanding of CLL and more effective therapies for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic lymphocytic leukemia who have high levels of CD38 expression.
Not a fit: Patients with other types of cancers or those without chronic lymphocytic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for patients with chronic lymphocytic leukemia, potentially improving their survival and quality of life.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting CD38 in other blood cancers, indicating potential for success in this area.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHINI, EDUARDO N — MAYO CLINIC JACKSONVILLE
- Study coordinator: CHINI, EDUARDO N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.