Understanding how CD28 costimulation affects T cell activation in cancer and viral infections
Cis-interaction mediated CD28 costimulation
This study is looking at how a special signal called CD28 helps activate T cells, which are important for fighting cancer and viral infections, by seeing if it can be turned on by molecules on the same T cell instead of from other cells, with the hope of finding better ways to boost the immune response in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11080112 on NIH RePORTER |
What this research studies
This research investigates the role of CD28, a critical costimulatory signal, in activating T cells, particularly in the context of cancer and viral infections. It aims to explore a novel mechanism where CD28 can be activated by B7 molecules on the same T cell, rather than from antigen-presenting cells. By understanding this unique interaction, the research seeks to enhance T cell responses against tumors and infections, potentially leading to improved immunotherapy strategies. The study will involve laboratory experiments to dissect the molecular mechanisms and functions of this cis-interaction.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or chronic viral infections who may benefit from enhanced T cell responses.
Not a fit: Patients with conditions unrelated to T cell dysfunction or those not experiencing cancer or viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for patients with cancer and viral infections.
How similar studies have performed: Other research has shown promise in enhancing T cell responses through costimulatory pathways, indicating that this approach may lead to significant advancements.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Zhao, Yunlong — St. Jude Children's Research Hospital
- Study coordinator: Zhao, Yunlong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.