Understanding how CD103 affects immune cell function in the intestines
Official title: CD103 engagement regulates intestinal IEL effector function
Funded at Rutgers Biomedical and Health Sciences · NIH-11032830 · Data updated 2026-11-12
This study is looking at how a protein called CD103 helps certain immune cells in the intestines work properly to keep you healthy and prevent issues like inflammatory bowel disease and celiac disease, with the goal of finding better treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | February 10, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $650,472 |
| NIH project number | 5R01AI170617-03 |
| Project ID | NIH-11032830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune conditions such as inflammatory bowel disease or celiac disease.
✕Less likely to help
Patients without autoimmune conditions or those not experiencing intestinal issues may not benefit from this research.
What this research studies
This research investigates the role of CD103, a protein found on certain immune cells in the intestines, in regulating the function of tissue-resident lymphocytes. These lymphocytes are crucial for maintaining the intestinal barrier and preventing infections. The study aims to explore how these immune cells respond to pathogens and how their activation is controlled, which is important for preventing conditions like inflammatory bowel disease and celiac disease. By examining the interactions between these cells and the intestinal environment, the research seeks to uncover mechanisms that could lead to better treatments for autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases affecting the intestines.
How similar studies have gone: Other research has shown promising results in understanding immune cell regulation in the intestines, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Bergsbaken, Tessa — Rutgers Biomedical and Health Sciences
- Study coordinator: Bergsbaken, Tessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.