Understanding how CD103 affects immune cell function in the intestines
CD103 engagement regulates intestinal IEL effector function
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11032830
This study is looking at how a protein called CD103 helps certain immune cells in the intestines work properly to keep you healthy and prevent issues like inflammatory bowel disease and celiac disease, with the goal of finding better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11032830 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CD103, a protein found on certain immune cells in the intestines, in regulating the function of tissue-resident lymphocytes. These lymphocytes are crucial for maintaining the intestinal barrier and preventing infections. The study aims to explore how these immune cells respond to pathogens and how their activation is controlled, which is important for preventing conditions like inflammatory bowel disease and celiac disease. By examining the interactions between these cells and the intestinal environment, the research seeks to uncover mechanisms that could lead to better treatments for autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune conditions such as inflammatory bowel disease or celiac disease.
Not a fit: Patients without autoimmune conditions or those not experiencing intestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases affecting the intestines.
How similar studies have performed: Other research has shown promising results in understanding immune cell regulation in the intestines, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERGSBAKEN, TESSA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: BERGSBAKEN, TESSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.