Understanding how CC16 helps the body respond to lung infections
Defining mechanisms of CC16 on epithelial-driven host responses to pathogens
This study is looking at a protein called CC16 to see how it helps people with asthma and COPD fight lung infections and keep their lungs healthy as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10996622 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called CC16 in the immune response to lung infections, particularly in patients with asthma and COPD. It aims to uncover how CC16 can protect against the decline in lung function that often occurs from childhood into adulthood. The study will explore how CC16 interacts with specific receptors in the body to limit inflammation and enhance the secretion of protective substances against viruses and bacteria. By understanding these mechanisms, the research hopes to identify new strategies for improving lung health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma or COPD, particularly those experiencing frequent lung infections.
Not a fit: Patients without asthma or COPD, or those who do not experience lung infections, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung function and reduce the severity of asthma and COPD.
How similar studies have performed: Previous studies have shown promising results in understanding the role of CC16 in lung health, suggesting that this approach has potential for significant advancements.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Ledford, Julie Gunnells — University of Arizona
- Study coordinator: Ledford, Julie Gunnells
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.