Understanding how CBD can help manage pain
Mechanism and optimization of CBD-mediated analgesic effects (Admin Supplement)
This study is looking at how cannabidiol (CBD) can help relieve chronic pain in adults by understanding how it works in the brain and spinal cord, so patients can learn more about using CBD for pain relief without the high that comes from THC.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10847933 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cannabidiol (CBD), a non-psychoactive component of cannabis, can effectively relieve chronic pain in adults. The study aims to explore how CBD interacts with specific receptors in the brain and spinal cord to enhance its pain-relieving effects. By examining the role of KCC2, a protein that helps regulate chloride levels in neurons, the researchers hope to optimize CBD's analgesic properties. Patients may benefit from a better understanding of how CBD can be used in pain management without the psychoactive effects associated with THC.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience chronic pain and are seeking alternative pain management options.
Not a fit: Patients who do not experience chronic pain or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies using CBD, providing relief for patients suffering from chronic pain.
How similar studies have performed: Previous research has shown promising results in using cannabinoids for pain management, but this specific approach focusing on CBD and KCC2 is relatively novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: He, Zhigang — Boston Children's Hospital
- Study coordinator: He, Zhigang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.