Understanding how Caspase-8 affects cancer and immune responses
THE FUNCTION OF CASPASE-8 IN CANCER, ANTI-CANCER IMMUNITY, AND CAR-T CELL FUNCTION
['FUNDING_FELLOWSHIP'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10999086
This study is looking at how a protein called Caspase-8 affects T cells and inflammation in cancer, which could help us understand how to make cancer treatments, like CAR-T cell therapy, work better for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10999086 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Caspase-8, a protein involved in cell death, in cancer and the immune system. It aims to explore how Caspase-8 influences T cell function and inflammatory responses in the context of cancer. By comparing cancer cells with and without Caspase-8, the research will assess its impact on tumor growth and the effectiveness of CAR-T cell therapy. This could lead to new insights into improving cancer treatments and enhancing anti-cancer immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with various cancers, particularly those undergoing or considering CAR-T cell therapy.
Not a fit: Patients with cancers that do not involve the Caspase-8 pathway or those who are not eligible for CAR-T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies and enhanced effectiveness of immunotherapies like CAR-T cell treatment.
How similar studies have performed: Previous research has shown promising results in understanding the role of apoptotic proteins in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAW, JEREMY JOSEPH PORTER — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: SHAW, JEREMY JOSEPH PORTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.