Understanding how Caspase-8 affects cancer and immune responses
Official title: THE FUNCTION OF CASPASE-8 IN CANCER, ANTI-CANCER IMMUNITY, AND CAR-T CELL FUNCTION
Funded at St. Jude Children's Research Hospital · NIH-10999086 · Data updated 2026-11-12
This study is looking at how a protein called Caspase-8 affects T cells and inflammation in cancer, which could help us understand how to make cancer treatments, like CAR-T cell therapy, work better for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32CA291105-01A1 |
| Project ID | NIH-10999086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with various cancers, particularly those undergoing or considering CAR-T cell therapy.
✕Less likely to help
Patients with cancers that do not involve the Caspase-8 pathway or those who are not eligible for CAR-T cell therapy may not benefit from this research.
What this research studies
This research investigates the role of Caspase-8, a protein involved in cell death, in cancer and the immune system. It aims to explore how Caspase-8 influences T cell function and inflammatory responses in the context of cancer. By comparing cancer cells with and without Caspase-8, the research will assess its impact on tumor growth and the effectiveness of CAR-T cell therapy. This could lead to new insights into improving cancer treatments and enhancing anti-cancer immunity.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies and enhanced effectiveness of immunotherapies like CAR-T cell treatment.
How similar studies have gone: Previous research has shown promising results in understanding the role of apoptotic proteins in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Shaw, Jeremy Joseph Porter — St. Jude Children's Research Hospital
- Study coordinator: Shaw, Jeremy Joseph Porter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.