Understanding how caspase-2 affects fat and cholesterol metabolism in the liver
Control of Lipogenesis and Hepatic Steatosis by Caspase-2
This study is looking at how a protein called caspase-2 affects fat and cholesterol levels in the liver, especially when the liver is under stress, to help find better treatments for liver diseases like non-alcoholic fatty liver disease (NAFLD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11086826 on NIH RePORTER |
What this research studies
This research investigates the role of caspase-2 in regulating fat and cholesterol metabolism in the liver, particularly under conditions of stress. It focuses on how caspase-2 influences two key pathways that control the production of fatty acids and cholesterol, which are crucial for maintaining liver health. By examining the interactions between these pathways, the research aims to uncover mechanisms that could lead to better treatments for liver diseases like non-alcoholic fatty liver disease (NAFLD). Patients may be involved in studies that explore these metabolic processes and their implications for liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with conditions related to liver metabolism, particularly those at risk for non-alcoholic fatty liver disease.
Not a fit: Patients with liver diseases unrelated to fat metabolism or those who do not have any liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver diseases associated with fat accumulation and inflammation.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways related to liver health, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Karin, Michael — University of California, San Diego
- Study coordinator: Karin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.