Understanding how carotid artery disease affects older patients' quality of life

Who could benefit from this research

What this research studies

This research investigates the impact of carotid artery stenosis on older patients, focusing on non-stroke outcomes such as cognitive decline, sleep disturbances, and mood changes. It aims to develop reliable methods for measuring these patient-reported outcomes, which will help determine if treatments like medication or surgery improve these symptoms. Patients diagnosed with carotid artery stenosis will be assessed at multiple time points to track changes in their quality of life and cognitive function over time.

Why it matters

Where this research is happening

• University of Utah
  Salt Lake City, United States Active

Researchers

• Principal investigator: Johnson, Cali — University of Utah
• Study coordinator: Johnson, Cali

Related research

Other NIH-funded projects on the same topics.

• Improving Decision Help for Older Adults Facing Carotid Artery Narrowing

  A patient-friendly project to create a decision aid to help older adults decide the best way to treat carotid artery stenosis with input from doctors and patients.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11265891

• Analyzing blood flow and plaque characteristics in carotid arteries to improve stroke risk assessment.

  This study is looking at how special MRI scans can help us understand the shape of plaque and blood flow in people with narrowed carotid arteries, especially those who don’t have symptoms, to see if we can better identify who might need surgery to prevent a stroke.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11257152

• Photon-counting CT vs conventional CT for carotid plaque in people with carotid artery stenosis

  This study tests whether photon-counting CT gives clearer, more detailed pictures of carotid plaques compared with standard CT in patients with carotid artery stenosis to help characterize plaque features.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07762664

• Carotid artery stent for people with carotid narrowing who are high risk for surgery

  This study will try a carotid artery stent system in adults with carotid artery narrowing who are considered high risk for carotid endarterectomy.

  Recruiting at 16 sites Beijing Tiantan Hospital · Beijing, Beijing Municipality and 15 other locations · NCT07370246

• Balloon guide catheter plus filter protection during carotid artery stenting

  This trial tests whether adding a balloon guide catheter to the usual distal filter during carotid artery stenting reduces debris-related brain injury in adults with symptomatic (≥50%) or asymptomatic (≥70%) carotid stenosis scheduled for stenting.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07247864

• Ultra-Intensive Lipid-Lowering Therapy in Carotid Artery Stenosis: PCSK9 Inhibitor Plus Statin vs Statin Alone

  This study tests whether adding a PCSK9 inhibitor to statin therapy improves the amount of atherosclerosis in people with carotid artery stenosis compared to statin therapy alone.

  Recruiting Changhai Hospital · Shanghai · NCT07036991

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.