Understanding how carnitine works as a treatment for chronic Chagas disease
Deciphering the mechanism of action of carnitine, a novel treatment for chronic Chagas disease
['FUNDING_R01'] · SAN DIEGO STATE UNIVERSITY · NIH-10873746
This study is looking at how L-carnitine might help improve heart health and lessen the symptoms of chronic Chagas disease, especially when used alongside the usual treatment, benznidazole, to find better options for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SAN DIEGO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-10873746 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of L-carnitine, a potential new treatment for chronic Chagas disease, which is caused by the Trypanosoma cruzi parasite. The study aims to uncover the mechanism by which L-carnitine improves heart health and reduces disease severity in patients. By examining its safety and effectiveness, especially in combination with the standard treatment benznidazole, the research seeks to provide a better therapeutic option for those affected by this condition. The findings could lead to improved treatment protocols and better patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic Chagas disease, particularly those experiencing cardiac complications.
Not a fit: Patients who do not have Chagas disease or those in the late stages of the disease where current treatments are ineffective may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients suffering from chronic Chagas disease.
How similar studies have performed: Previous research has shown promise in using L-carnitine for treating metabolic disorders, but its application in Chagas disease is relatively novel and untested.
Where this research is happening
SAN DIEGO, UNITED STATES
- SAN DIEGO STATE UNIVERSITY — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCALL, LAURA-ISOBEL — SAN DIEGO STATE UNIVERSITY
- Study coordinator: MCCALL, LAURA-ISOBEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.