Understanding how cardiac signaling changes in disease and stress
Dysregulation of cardiac signaling in disease and stress
This study is looking at a protein called GRK2 to see how it affects heart health during tough times, like after a heart attack, and it hopes to find new ways to help people with heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11079619 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, G-protein coupled receptor kinase-2 (GRK2), in heart conditions such as hypertrophy and heart failure. It focuses on how GRK2 is activated during cardiac stress and how it affects heart cell metabolism, particularly after events like a heart attack. By using specialized mouse models, the research aims to uncover the mechanisms by which GRK2 influences heart function and energy use, potentially leading to new treatment strategies for heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced cardiac conditions such as heart failure or myocardial infarction.
Not a fit: Patients with non-cardiac related conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and recovery after cardiac events.
How similar studies have performed: Previous research has shown promising results in understanding cardiac signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Sato, Priscila — University of Alabama at Birmingham
- Study coordinator: Sato, Priscila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.