Understanding how cardiac muscle contraction is regulated in health and disease.
The mechanisms of cardiac thin filament regulation in health and disease.
This study is looking at how certain proteins help your heart muscle contract and how changes in these proteins might lead to heart diseases, with the hope of finding new ways to treat or manage these conditions for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-11003287 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cardiac muscle contraction is regulated, focusing on the role of specific proteins involved in this process. By using advanced imaging techniques, the study aims to reveal the structure of the troponin complex, which is crucial for muscle function. The research will explore how genetic variants in troponin can lead to common heart diseases, such as cardiomyopathies, by affecting the regulation of muscle contraction. Patients may benefit from insights that could lead to new treatments or management strategies for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with familial cardiomyopathies or those with known troponin variants.
Not a fit: Patients without genetic predispositions to cardiomyopathies or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with genetic heart diseases.
How similar studies have performed: Previous research has shown promise in understanding cardiac muscle regulation, but this approach using advanced imaging techniques is relatively novel.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Galkin, Vitold — Old Dominion University
- Study coordinator: Galkin, Vitold
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.