Understanding how carbohydrates affect protein structure and function
Glycosylation as a Structural Determinant in Peptide Fibrillization
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-10649457
This study is looking at how adding sugars to proteins affects how they shape and work, which could help create new materials that act like natural proteins and might be useful in medicine.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10649457 on ClinicalTrials.gov |
What this research studies
This research investigates the role of glycosylation, the addition of carbohydrates to proteins, in determining how proteins fold and function. By creating carbohydrate-modified peptides that can self-assemble into structures similar to glycosylated proteins, the research aims to uncover how changes in glycosylation influence protein behavior. The findings could lead to the development of new biomaterials that mimic natural proteins, potentially improving their performance in medical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or those who may benefit from advanced biomaterials in medical treatments.
Not a fit: Patients with conditions unrelated to protein structure or those not requiring biomaterials for treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative biomaterials that enhance the treatment of various diseases by improving the functionality of proteins in the body.
How similar studies have performed: Other research has shown promising results in understanding glycosylation's role in protein function, suggesting that this approach could yield valuable insights.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUDALLA, GREGORY — UNIVERSITY OF FLORIDA
- Study coordinator: HUDALLA, GREGORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.