Understanding how CAR T-cell therapy can cause neurotoxicity
Unraveling the Pathophysiology of Neurotoxicity Induced by CAR T-cells
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10891435
This study is looking into the brain-related side effects that some people experience after receiving CAR T-cell therapy for blood cancers, using special mice to help us understand why these issues happen and how we can make the treatment safer for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10891435 on ClinicalTrials.gov |
What this research studies
This research investigates the adverse neurological effects associated with CAR T-cell therapy, a treatment for B-cell leukemias and lymphomas. By using a novel humanized mouse model, the study aims to replicate the neurological adverse effects seen in patients, which can range from mild disorientation to severe complications. The goal is to better understand the underlying mechanisms of these side effects, which are currently not well understood, to improve patient outcomes and treatment safety. The research involves genetic engineering of T-cells and monitoring their effects on the nervous system in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with B-cell malignancies who are considering or undergoing CAR T-cell therapy.
Not a fit: Patients with non-B-cell malignancies or those not receiving CAR T-cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and management of neurotoxic side effects in patients undergoing CAR T-cell therapy.
How similar studies have performed: While the approach of using humanized mouse models is established, the specific investigation into CAR T-cell induced neurotoxicity is relatively novel and has not been extensively studied.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENNELL, CHRISTOPHER A — UNIVERSITY OF MINNESOTA
- Study coordinator: PENNELL, CHRISTOPHER A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.