Understanding how capillary cells change into arterial cells in pulmonary arterial hypertension
Official title: General Capillary to Arterial Endothelial Cell Transition in Pulmonary ArterialHypertension
Funded at Washington University · NIH-11175168 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs change and may contribute to pulmonary arterial hypertension (PAH), with the goal of finding new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $715,847 |
| NIH project number | 7R01HL170096-02 |
| Project ID | NIH-11175168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
✕Less likely to help
Patients with other forms of hypertension not related to pulmonary arterial hypertension may not benefit from this research.
What this research studies
This research investigates the mechanisms behind pulmonary arterial hypertension (PAH), a condition that leads to increased pressure in the lungs and can cause heart failure. The study focuses on how capillary endothelial cells transition into arterial endothelial cells, which may contribute to the disease's progression. By examining specific signaling pathways involved in this process, the researchers aim to uncover new therapeutic strategies that could improve treatment outcomes for patients with PAH.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or reverse pulmonary arterial hypertension.
How similar studies have gone: Previous research has shown promising results in understanding endothelial cell transitions in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Dai, Zhiyu — Washington University
- Study coordinator: Dai, Zhiyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.