Understanding how cannabis withdrawal affects the brain in adolescents
Glutamatergic plasticity that drives cannabinoid withdrawal and craving
This study is looking at how using cannabis during the teenage years affects brain function and cravings when someone stops using it, with the goal of finding better treatments for young people struggling with cannabis use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10907772 on NIH RePORTER |
What this research studies
This research investigates the effects of chronic cannabis use during adolescence on brain function, specifically focusing on glutamatergic transmission in a brain region called the nucleus accumbens. The study aims to understand how withdrawal from cannabis can lead to cravings and relapse, particularly in young individuals. By examining the neurobiological changes that occur during abstinence, the research seeks to identify potential targets for new treatments for cannabis use disorder. The approach includes both behavioral assessments and neurobiological analyses to provide a comprehensive understanding of the issue.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who have a history of cannabis use and may be experiencing withdrawal symptoms.
Not a fit: Patients who have never used cannabis or are outside the age range of 12 to 20 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for adolescents struggling with cannabis use disorder and withdrawal symptoms.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological impacts of substance use, indicating that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Spencer, Sade Monique — University of Minnesota
- Study coordinator: Spencer, Sade Monique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.