Understanding how cannabinoid system signals work in the body
Project 3 - In vivo pharmacology of cannabinoid receptor probes
This research explores how the body's natural cannabinoid system works to find new ways to create safer and more effective medicines for conditions like anxiety.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11128518 on NIH RePORTER |
What this research studies
Our bodies have a natural system, called the endocannabinoid system, that plays a role in many functions, including pain and mood. This project looks at how different signals within this system can be targeted to develop new medications. We are exploring new ways to activate specific pathways that might offer therapeutic benefits while avoiding unwanted side effects. By understanding these pathways better, we hope to bridge the gap between early lab discoveries and new treatments for patients.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit future patients with conditions like anxiety or chronic pain who might benefit from new cannabinoid-based therapies.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial will not find direct benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more effective, and safer medications for conditions that involve the endocannabinoid system, such as anxiety.
How similar studies have performed: While the concept of functional selectivity and biased agonism is relatively new in this field, it represents a promising alternative strategy for drug development.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Hohmann, Andrea Grace — Northeastern University
- Study coordinator: Hohmann, Andrea Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.