Understanding how Candida yeast colonizes the gastrointestinal tract
Official title: Candida Determinants of GI Tract Colonization
Funded at Sloan-Kettering Inst Can Research · NIH-11061770 · Data updated 2026-11-12
This study is looking at how a type of yeast called Candida, especially Candida albicans, settles in the gut and how this can affect gut health and infections, particularly for people with inflammatory bowel disease or weakened immune systems.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $525,070 |
| NIH project number | 5P01AI179406-02 |
| Project ID | NIH-11061770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory bowel disease (IBD) or those who are immunocompromised.
✕Less likely to help
Patients without gastrointestinal issues or those who are not immunocompromised may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Candida species, particularly Candida albicans, colonize the gastrointestinal (GI) tract and how this affects both gut health and systemic infections. The study focuses on the different forms of Candida cells and their behavior in the gut environment, especially in relation to inflammatory bowel disease (IBD) and immunocompromised individuals. By examining how changes in the gut microbiota influence Candida colonization, the research aims to fill critical knowledge gaps regarding fungal infections and their impact on health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating systemic fungal infections, particularly in vulnerable populations.
How similar studies have gone: Previous studies have shown that understanding the behavior of Candida in the gut can lead to significant insights into fungal infections, indicating that this research builds on established findings.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hohl, Tobias M — Sloan-Kettering Inst Can Research
- Study coordinator: Hohl, Tobias M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.