Understanding how Candida species become resistant to antifungal drugs
Aneuploidy and Acquired Antifungal Drug Resistance in Candida species
This study is looking at how certain fungi, like Candida, quickly become resistant to common antifungal medications, like fluconazole, to help find better treatments for people dealing with these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10731749 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the rapid development of drug resistance in Candida species, particularly focusing on azole antifungals like fluconazole. By using advanced techniques, the researchers aim to observe how these fungi adapt and change at a genetic level when exposed to antifungal treatments. The study will involve both laboratory experiments and genetic analysis to uncover the factors that contribute to resistance, which could lead to more effective treatment strategies for patients with Candida infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with recurrent or persistent Candida infections that have shown resistance to antifungal treatments.
Not a fit: Patients with Candida infections that are easily treatable with existing antifungal medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from drug-resistant Candida infections.
How similar studies have performed: Previous research has shown that understanding genetic changes in pathogens can lead to breakthroughs in treatment, suggesting that this approach may yield significant insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Selmecki, Anna M. — University of Minnesota
- Study coordinator: Selmecki, Anna M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.