Understanding how Candida infections affect patients' outcomes
Official title: Epigenomic Mechanisms & STAT Networks in Persistent CA Candidemia
Funded at Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · NIH-11091670 · Data updated 2026-11-12
This study is looking at how certain genes and immune responses affect the outcomes for patients with a serious bloodstream infection caused by a fungus called Candida albicans, to help find better ways to diagnose and treat this dangerous condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project start | August 10, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,216 |
| NIH project number | 5U19AI172713-03 |
| Project ID | NIH-11091670 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients diagnosed with candidemia, particularly those experiencing severe or persistent infections.
✕Less likely to help
Patients with non-fungal bloodstream infections or those who are not hospitalized may not benefit from this research.
What this research studies
This research investigates the serious bloodstream infection caused by the fungus Candida albicans, which can lead to high mortality rates in hospitalized patients. By analyzing samples from a biorepository of patients with candidemia, the study aims to identify genetic and immune factors that influence patient outcomes. The research will compare samples from patients who survived the infection to those who did not, focusing on the characteristics of both the fungus and the host. This approach seeks to uncover new diagnostic and treatment strategies for this life-threatening condition.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from severe Candida infections.
How similar studies have gone: Previous research has shown promising results in understanding fungal infections and their impact on patient outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, United States Active
Researchers
- Principal investigator: Filler, Scott G — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Filler, Scott G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.