Understanding how Candida glabrata becomes resistant to antifungal treatments
Official title: Novel mechanisms of azole resistance in clinical isolates of Candida glabrata
Funded at University of Iowa · NIH-11058413 · Data updated 2026-11-12
This study is looking into how the fungus Candida glabrata becomes resistant to antifungal medicines like fluconazole, so we can find better ways to help patients who have infections caused by this tough fungus.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $236,772 |
| NIH project number | 5R21AI180916-02 |
| Project ID | NIH-11058413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with bloodstream infections caused by Candida glabrata.
✕Less likely to help
Patients with infections caused by other species of Candida or those not infected with Candida will likely not benefit from this research.
What this research studies
This research investigates the mechanisms by which the fungus Candida glabrata develops resistance to antifungal medications, particularly fluconazole. By analyzing clinical isolates of C. glabrata, the study aims to identify genetic mutations and changes in protein expression that contribute to this resistance. The researchers will utilize whole genome sequencing and protein analysis techniques to explore these mechanisms in detail. This work is crucial for developing better treatment strategies for patients suffering from infections caused by this resistant fungus.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with Candida glabrata infections, potentially reducing mortality rates.
How similar studies have gone: Previous studies have shown success in understanding antifungal resistance mechanisms in other fungi, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Moye-Rowley, W Scott — University of Iowa
- Study coordinator: Moye-Rowley, W Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.