Understanding how Candida auris causes infections
Mechanism(s) of pathogenicity for Candida auris
This study is looking at how the fungus Candida auris manages to avoid being attacked by our immune system, especially the white blood cells that help fight infections, so that new treatments can be developed for people dealing with serious fungal infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11054581 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the fungal pathogen Candida auris evades the immune system, particularly focusing on how it resists being killed by neutrophils, which are crucial for fighting infections. The researchers aim to uncover the molecular details of this immune evasion to identify new drug targets and develop innovative therapies. By studying the unique properties of C. auris and its interactions with immune cells, the project seeks to enhance our understanding of this dangerous pathogen and improve treatment options for patients with invasive fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from invasive fungal infections, particularly those caused by Candida auris or other drug-resistant fungi.
Not a fit: Patients with fungal infections that are not caused by Candida auris or those who do not have invasive fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat infections caused by drug-resistant fungi, significantly improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding immune evasion by pathogens, suggesting that this approach could yield valuable insights and therapeutic advancements.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Nett, Jeniel E — University of Wisconsin-Madison
- Study coordinator: Nett, Jeniel E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.