Understanding how Candida albicans senses low copper levels
Investigation of the role of CuZnSod1 in sensing Cu-deficient conditions in Candida albicans
This study looks at how the fungus Candida albicans senses and reacts to low copper levels, which is important for its survival in people, and it aims to find ways to make treatments more effective by understanding a specific protein that helps the fungus adapt.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10822680 on NIH RePORTER |
What this research studies
This research investigates how the fungus Candida albicans detects and responds to low copper conditions, which is crucial for its survival in human hosts. The study focuses on the role of a specific protein, CuZnSod1, and its interactions with other proteins and genes that help the fungus adapt to varying copper levels. By examining these mechanisms, the research aims to uncover potential vulnerabilities in the fungus that could be targeted for treatment. Patients may benefit from insights that could lead to more effective antifungal therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from Candida albicans infections, especially those who are immunocompromised or have recurrent infections.
Not a fit: Patients with infections caused by other types of fungi or those who do not have Candida albicans infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Candida albicans, particularly in patients with compromised immune systems.
How similar studies have performed: Other research has shown success in targeting fungal responses to nutrient availability, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Vaccaro, Francesca — Duke University
- Study coordinator: Vaccaro, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.