Understanding how Candida albicans responds to stress in the body
Official title: Translational Control of Host Environmental Stress Responses in Candida albicans
Funded at University of Texas Hlth Science Center · NIH-10905521 · Data updated 2026-11-12
This study looks at how the Candida albicans fungus changes and grows in people with weakened immune systems, aiming to find out how it survives in tough conditions, which could help develop better treatments for those at risk of serious infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $247,348 |
| NIH project number | 1R01AI178973-01A1 |
| Project ID | NIH-10905521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with weakened immune systems, such as those with AIDS, cancer patients undergoing chemotherapy, and organ transplant recipients.
✕Less likely to help
Patients with healthy immune systems or those not at risk for Candida infections may not benefit from this research.
What this research studies
This research investigates how the fungus Candida albicans, which can cause serious infections in immunocompromised patients, adapts to environmental stressors in the body. The study focuses on the mechanisms that control the transition of Candida from a yeast form to a more invasive filamentous form, particularly through the role of specific proteins that regulate gene translation. By examining these processes, the research aims to uncover new insights into how this pathogen survives and thrives in vulnerable patients, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for preventing and treating Candida infections in immunocompromised patients.
How similar studies have gone: Other research has shown success in understanding fungal pathogen responses, but this specific focus on translational control mechanisms in Candida albicans is relatively novel.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Kadosh, David — University of Texas Hlth Science Center
- Study coordinator: Kadosh, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.