Understanding how Candida albicans grows in the gut
Molecular mechanisms of Candida albicans gut colonization
This study is looking at how the fungus Candida albicans lives in the gut, where it can be harmless but sometimes causes infections if it grows too much, and it's for anyone interested in understanding how this fungus behaves so we can find better ways to diagnose and treat related infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11087680 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the fungus Candida albicans colonizes the gut, where it can exist harmlessly but may also cause infections if it overgrows. The team uses advanced genetic techniques to identify specific factors that help this fungus thrive in the gut environment. By studying these factors in a mouse model, they aim to uncover how Candida transitions from a harmless state to one that can cause disease. This knowledge could lead to better diagnostic tools and treatments for fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of recurrent fungal infections or those at risk of developing such infections.
Not a fit: Patients who do not have any history of fungal infections or related gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and treating fungal infections caused by Candida albicans.
How similar studies have performed: Previous research has shown success in understanding microbial colonization in other contexts, but this specific focus on Candida albicans is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Noble, Suzanne M — University of California, San Francisco
- Study coordinator: Noble, Suzanne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.