Understanding how Candida albicans changes its form and behavior
Genetic Regulation of Heritable Switching in Candida albicans
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10542381
This study is looking at how the fungus Candida albicans changes its form, which can make it more likely to cause infections, especially in people with weakened immune systems, to help find better treatments for those infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10542381 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mechanisms that allow the fungus Candida albicans to switch between different forms, which can affect its ability to cause infections. By studying how these changes occur, the research aims to uncover why some strains of this fungus are more likely to lead to disease, especially in individuals with weakened immune systems. The approach involves examining the genetic and epigenetic factors that influence these transitions, which could help in developing better treatments for infections caused by this organism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems who are at risk for Candida infections.
Not a fit: Patients who do not have any risk factors for Candida infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating infections caused by Candida albicans.
How similar studies have performed: Other research has shown success in understanding fungal behavior and its implications for treatment, making this approach promising.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENNETT, RICHARD JOHN — BROWN UNIVERSITY
- Study coordinator: BENNETT, RICHARD JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.