Understanding how Candida albicans changes and interacts with the body
Transcriptional Regulation of C. albicans Cell Fate and Host Interactions
This project explores how the common fungus Candida albicans changes its form to live in or infect different parts of the human body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11140428 on NIH RePORTER |
What this research studies
Candida albicans is a fungus that often lives harmlessly in our bodies but can also cause serious infections. This fungus is very adaptable, able to switch between different forms and behaviors, which helps it survive and cause disease. Our work looks closely at the internal controls, called transcription factors, that tell Candida how to change. By understanding these controls, we hope to learn how Candida makes decisions about whether to live peacefully or cause an infection.
Who could benefit from this research
Good fit: Patients who experience recurrent or severe Candida infections may ultimately benefit from the discoveries made in this basic science.
Not a fit: Patients who do not have Candida infections or related health concerns would not directly benefit from this specific research.
Why it matters
Potential benefit: This work could lead to new ways to prevent or treat Candida infections by targeting the fungus's ability to adapt and cause disease.
How similar studies have performed: While previous work has identified some factors controlling Candida's development, this project explores a novel mechanism involving how these factors work together.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Bennett, Richard John — Brown University
- Study coordinator: Bennett, Richard John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.