Understanding how Candida albicans causes infections in humans
Regulation of Candida albicans Pathogenesis by Protein Kinase and Transcription Factor Networks
This study is looking at how the fungus Candida albicans can change from being harmless to causing serious infections, and it aims to find out what genes and proteins are involved in this process, which could help develop better treatments for patients dealing with these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11043352 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the fungus Candida albicans transitions from harmless colonization to causing serious infections. It focuses on the genetic networks involving protein kinases and transcription factors that regulate this process. By using advanced techniques like RNA sequencing, the research aims to identify key factors that contribute to mucosal infections and potentially severe bloodstream infections. Patients may benefit from insights that could lead to new antifungal treatments or prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised or have a history of recurrent Candida infections.
Not a fit: Patients with non-fungal infections or those who do not have a history of Candida-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Candida albicans, particularly for vulnerable populations.
How similar studies have performed: Previous research has shown success in understanding fungal pathogenesis, indicating that this approach could yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Krysan, Damian J — University of Iowa
- Study coordinator: Krysan, Damian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.