Understanding how Candida albicans causes infections
Quantitative genetic approaches to Candida albicans pathogenesis
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10833504
This study is looking at how certain genes in the Candida albicans fungus can change it from being harmless to causing infections, especially in the mouth, to help us find better ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10833504 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that influence how the fungus Candida albicans can transition from a harmless organism to a harmful pathogen. By examining different strains of C. albicans, the study aims to identify the genetic variations that affect its ability to grow and invade human tissues, particularly in the oral cavity. The researchers will use advanced genetic techniques to analyze how these variations impact the fungus's behavior and its interaction with human cells. This work could lead to better understanding and treatment of infections caused by this common fungus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of Candida infections, such as those with compromised immune systems or underlying health conditions.
Not a fit: Patients who do not have any history of Candida infections or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Candida albicans, particularly for patients with weakened immune systems.
How similar studies have performed: Previous research has shown success in understanding fungal pathogenesis through genetic approaches, indicating that this study builds on established methods.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSON, MATTHEW Z — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: ANDERSON, MATTHEW Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.