Understanding how Candida albicans becomes resistant to antifungal treatment
Molecular mechanisms of caspofungin susceptibility in the pathogen Candida albicans
This study is looking at why the common fungus Candida albicans doesn't respond well to the antifungal drug caspofungin, with the hope of finding better ways to treat people who have serious infections caused by this fungus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10615659 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the resistance of the common fungal pathogen Candida albicans to the antifungal drug caspofungin. By examining how certain genetic changes in the fungus affect its susceptibility to treatment, the researchers aim to identify new factors that contribute to resistance. The study involves laboratory experiments where C. albicans is exposed to caspofungin to observe changes in its genetic makeup and cell structure. The goal is to uncover insights that could lead to improved treatment strategies for patients suffering from invasive candidiasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from invasive candidiasis, particularly those who have experienced treatment failures with current antifungal therapies.
Not a fit: Patients with non-fungal infections or those who do not have a history of candidiasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with resistant Candida infections.
How similar studies have performed: Other research has shown success in identifying resistance mechanisms in fungal pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Rustchenko, Elena — University of Rochester
- Study coordinator: Rustchenko, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.