Understanding how Candida albicans adapts to different body environments
Tissue specific immunity to fungal infections
['FUNDING_R01'] · HACKENSACK UNIVERSITY MEDICAL CENTER · NIH-11058914
This study is looking at how a common fungus called Candida albicans changes to survive in different parts of the body, especially in people with weakened immune systems, and it focuses on a specific protein that helps the fungus resist treatments, so we can better understand how to fight these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HACKENSACK UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (HACKENSACK, UNITED STATES) |
| Trial ID | NIH-11058914 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses to Candida albicans, a common fungal pathogen that can cause serious infections, particularly in immunocompromised individuals. The study focuses on how this fungus adapts to various environments in the body, such as the oral cavity and systemic circulation, by examining the role of a specific protein, Gcn5, which modifies other proteins to help the fungus survive and resist antifungal treatments. By using animal models, researchers aim to uncover the mechanisms behind these adaptations and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals who are at higher risk for serious fungal infections.
Not a fit: Patients with non-fungal infections or those who are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for fungal infections, particularly for vulnerable patients.
How similar studies have performed: Previous research has shown promising results in understanding fungal pathogenesis and antifungal resistance, indicating that this approach has potential for success.
Where this research is happening
HACKENSACK, UNITED STATES
- HACKENSACK UNIVERSITY MEDICAL CENTER — HACKENSACK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAUHAN, NEERAJ — HACKENSACK UNIVERSITY MEDICAL CENTER
- Study coordinator: CHAUHAN, NEERAJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.