Understanding how cancer treatments affect blood vessel health
Official title: Investigating the role of apoptosis regulation in cancer therapy-induced vascular toxicities
Funded at Harvard School of Public Health · NIH-10999437 · Data updated 2026-11-12
This study is looking at how cancer treatments can harm blood vessels, which might lead to heart problems or blood clots, and it's for anyone who has undergone cancer therapy to help make these treatments safer in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $35,183 |
| NIH project number | 5F31CA275321-03 |
| Project ID | NIH-10999437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are undergoing or have undergone cancer treatment.
✕Less likely to help
Patients who are not currently receiving cancer treatment or those with non-cancer-related vascular issues may not benefit from this research.
What this research studies
This research investigates the harmful effects of cancer therapies on blood vessels, which can lead to serious health issues like heart failure and blood clots. By using human stem cells, the team will study how different types of cancer treatments cause damage to vascular cells. The goal is to identify which cells are most affected and how this damage contributes to long-term health problems in patients after treatment. This could help improve the safety and effectiveness of cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer treatments that minimize damage to blood vessels and improve patient outcomes.
How similar studies have gone: Previous research has shown that understanding cellular responses to cancer therapies can lead to significant improvements in treatment safety, indicating potential success for this approach.
Where this research is happening
-
Harvard School of Public Health
Boston, United States Active
Researchers
- Principal investigator: Florido, Mary Heather Celine — Harvard School of Public Health
- Study coordinator: Florido, Mary Heather Celine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.