Understanding how cancer mutations affect protein production
Official title: An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer
Funded at University of Virginia · NIH-11044131 · Data updated 2026-11-12
This study is looking at how changes in cancer genes can create different versions of proteins that might affect how cancer grows, with the goal of finding new ways to tailor treatments for patients based on their specific genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $396,073 |
| NIH project number | 5R33CA281919-02 |
| Project ID | NIH-11044131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients with known genetic mutations that may affect protein splicing.
✕Less likely to help
Patients without identifiable genetic mutations or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research investigates how certain mutations in cancer genes can lead to the production of different protein forms, which may influence cancer progression. By using advanced technologies, the team aims to identify specific biomarkers and drug targets that can improve cancer therapies. The approach combines experimental techniques with computational analysis to create a detailed understanding of how these mutations affect cancer at a molecular level. Patients may benefit from more personalized and effective treatment options based on their unique genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more targeted and effective cancer therapies tailored to individual patients' genetic mutations.
How similar studies have gone: Previous research has shown promise in linking genetic mutations to cancer progression, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Sheynkman, Gloria — University of Virginia
- Study coordinator: Sheynkman, Gloria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.