Understanding how cancer genes cause stress in DNA replication
Defining the molecular basis of oncogene-induced replication stress
This study is looking at how certain genes that can cause cancer mess up the way our cells copy their DNA, which might lead to cancer, and it’s for anyone interested in understanding how these early changes happen before cancer develops, so we can find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10975047 on NIH RePORTER |
What this research studies
This research investigates how certain cancer-causing genes, known as oncogenes, disrupt normal DNA replication processes in cells, leading to genomic instability and potentially cancer. The study aims to identify the early mechanisms that trigger this replication stress and how cells respond to it over time. By using advanced techniques to analyze precancerous cells, the research seeks to uncover critical insights into the cellular changes that occur before cancer develops. This could help in developing targeted therapies that address these early disruptions in DNA replication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those who have been exposed to environmental carcinogens.
Not a fit: Patients with established cancer who are already undergoing treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancer by targeting the early stages of genomic instability.
How similar studies have performed: Previous research has shown that understanding the mechanisms of oncogene-induced stress can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Huang, Tony Tung — New York University School of Medicine
- Study coordinator: Huang, Tony Tung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.