Understanding how cancer evolves resistance to treatment using mathematical models.
Official title: Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11114667 · Data updated 2026-11-12
This study is looking at how cancer can become resistant to certain treatments, like tyrosine kinase inhibitors, and aims to find new ways to help patients by understanding these changes better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $192,327 |
| NIH project number | 3U01CA280829-02S1 |
| Project ID | NIH-11114667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers that are currently treated with tyrosine kinase inhibitors and who may be experiencing or at risk of developing resistance.
✕Less likely to help
Patients with cancers that do not involve tyrosine kinase mutations or those who are not receiving targeted therapies may not benefit from this research.
What this research studies
This research investigates the evolutionary processes that lead to resistance in cancer treatments, particularly focusing on tyrosine kinase inhibitors. By employing mathematical modeling and an innovative evolutionary game assay, the study aims to connect theoretical insights with real biological and clinical data. This approach seeks to understand the dynamics of cancer evolution in a way that could inform more effective treatment strategies. Patients may benefit from insights that could lead to new therapeutic approaches that circumvent resistance.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that overcome resistance, improving patient outcomes.
How similar studies have gone: While the theoretical modeling of cancer evolution has been explored, this specific approach integrating empirical biology with evolutionary game theory is relatively novel and untested.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Scott, Jacob Gardinier — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Scott, Jacob Gardinier
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.