Understanding how cancer drugs work at a molecular level
Official title: CHARACTERIZING THE MECHANISM OF ACTION (MOA) OF INVESTIGATIONAL/APPROVED CANCER AGENTS
Funded at Leidos Biomedical Research, INC. · NIH-10941126 · Data updated 2026-11-12
This study is looking at how different cancer treatments work in the body and how they can be improved, so that patients can have better options for fighting their cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project start | September 22, 2023 |
| Project end | September 21, 2028 |
| Funding year | 2023 |
| Award (this year) | $5,659,274 |
| NIH project number | 75N91019D00024-0-759102300019-1 |
| Project ID | NIH-10941126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancer who are undergoing treatment or considering new investigational therapies.
✕Less likely to help
Patients with non-cancerous conditions or those not currently receiving cancer treatment may not benefit from this research.
What this research studies
This research investigates the mechanisms of action of both approved and investigational cancer treatments by studying their effects on various biological systems. The approach involves detailed molecular pharmacology studies that examine how these drugs interact with cellular pathways, how tumors may resist treatment, and how the immune system responds to these therapies. By dissecting these complex interactions, the research aims to provide insights that could enhance the development of more effective cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that are more effective and tailored to individual patient needs.
How similar studies have gone: Similar research has shown success in elucidating drug mechanisms, which has led to advancements in cancer treatment strategies.
Where this research is happening
-
Leidos Biomedical Research, INC.
Frederick, United States Active
Researchers
- Principal investigator: Parchment, Ralph — Leidos Biomedical Research, INC.
- Study coordinator: Parchment, Ralph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.