Understanding how cancer drugs affect blood vessel health
Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCs
This study is looking at how cancer treatments called tyrosine kinase inhibitors (TKIs) might affect blood vessel health, and it's for people who are using these medications; the goal is to find ways to make these treatments safer and reduce risks like high blood pressure and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10854988 on NIH RePORTER |
What this research studies
This research investigates the harmful effects of tyrosine kinase inhibitors (TKIs), which are used to treat cancer, on blood vessel function. By using human-induced pluripotent stem cells (iPSCs), the team will explore the cellular mechanisms that lead to vascular toxicity, which can cause serious health issues like hypertension and heart attacks. The study employs advanced techniques such as multi-omics methods and CRISPR screening to identify potential therapeutic targets that could mitigate these side effects. Patients may benefit from improved treatment strategies that enhance the safety of TKIs.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are currently receiving or have received tyrosine kinase inhibitors.
Not a fit: Patients who are not undergoing treatment with tyrosine kinase inhibitors or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer treatments that minimize vascular complications for patients taking TKIs.
How similar studies have performed: Previous research has shown promising results in understanding drug-induced vascular toxicity, but this specific approach using iPSCs and CRISPR is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wu, Joseph C. — Stanford University
- Study coordinator: Wu, Joseph C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.