Understanding how cancer develops and progresses
Official title: Tipping Points in Cancer
Funded at University of California-Irvine · NIH-11016816 · Data updated 2026-11-12
This study is looking at how different factors, both genetic and environmental, help cancer start and grow, using mice to learn more about how cells behave in different types of cancer, like leukemia and breast cancer, so we can find better ways to prevent and treat these diseases.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $2,186,372 |
| NIH project number | 1P01CA288662-01A1 |
| Project ID | NIH-11016816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for breast cancer, chronic myeloid leukemia, or melanoma, particularly those with specific genetic backgrounds.
✕Less likely to help
Patients with cancers not related to the specific types being studied or those who do not have the relevant genetic predispositions may not benefit from this research.
What this research studies
This research investigates the complex processes involved in the initiation and progression of cancer, focusing on both genetic and non-genetic factors. It employs advanced mouse models to study how cell interactions and states contribute to the transition from pre-malignant to malignant conditions. By examining various types of cancer, including chronic myeloid leukemia, melanoma, and triple-negative breast cancer, the research aims to uncover critical thresholds that could inform better prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and prevention strategies for various types of cancer.
How similar studies have gone: Previous research has shown promise in understanding cancer progression through similar approaches, indicating potential for significant advancements in treatment.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Lowengrub, John — University of California-Irvine
- Study coordinator: Lowengrub, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.