Understanding how cancer develops and progresses
Tipping Points in Cancer
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11016816
This study is looking at how different factors, both genetic and environmental, help cancer start and grow, using mice to learn more about how cells behave in different types of cancer, like leukemia and breast cancer, so we can find better ways to prevent and treat these diseases.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11016816 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes involved in the initiation and progression of cancer, focusing on both genetic and non-genetic factors. It employs advanced mouse models to study how cell interactions and states contribute to the transition from pre-malignant to malignant conditions. By examining various types of cancer, including chronic myeloid leukemia, melanoma, and triple-negative breast cancer, the research aims to uncover critical thresholds that could inform better prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for breast cancer, chronic myeloid leukemia, or melanoma, particularly those with specific genetic backgrounds.
Not a fit: Patients with cancers not related to the specific types being studied or those who do not have the relevant genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and prevention strategies for various types of cancer.
How similar studies have performed: Previous research has shown promise in understanding cancer progression through similar approaches, indicating potential for significant advancements in treatment.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOWENGRUB, JOHN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: LOWENGRUB, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Breast Cancer, Cancer Biology, cancer initiation