Understanding how cancer cells survive stress in their environment
Official title: Molecular Mechanisms Underlying Cell Survival During Endoplasmic Reticulum Stress
Funded at California State University Long Beach · NIH-10811665 · Data updated 2026-11-12
This study is looking at how cancer cells cope with tough conditions in their environment and trying to find ways to make them more sensitive to treatments, which could help develop better therapies for cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Long Beach NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project start | May 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $110,625 |
| NIH project number | 5SC3GM139707-04 |
| Project ID | NIH-10811665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer who may benefit from new treatment strategies aimed at overcoming cancer cell resistance.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancer is already at an advanced stage may not benefit from this research.
What this research studies
This research investigates how cancer cells manage stress from their environment, particularly focusing on a cellular process called endoplasmic reticulum (ER) stress. When cells experience this stress, they activate a protective response to survive, but if the stress continues, they may die. The study aims to uncover the molecular mechanisms that allow cancer cells to adapt and survive under these stressful conditions, which could lead to new cancer treatments. By examining specific pathways that promote cell survival, the research seeks to identify potential targets for therapies that could make cancer cells more vulnerable to treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the effectiveness of cancer treatments by targeting the survival mechanisms of cancer cells.
How similar studies have gone: Previous research has shown that targeting cellular stress responses can improve treatment outcomes in cancer, indicating that this approach has potential for success.
Where this research is happening
-
California State University Long Beach
Long Beach, United States Active
Researchers
- Principal investigator: Bhandari, Deepali — California State University Long Beach
- Study coordinator: Bhandari, Deepali
Related research
Other NIH-funded projects on the same topics.
-
Synthesis of Dihydrobenzofuran Natural Products That Modulate Immune Response
A scientist plans to make new dihydrobenzofuran compounds in the lab that could help reduce inflammation and potentially aid conditions like Alzheimer’s disease.
-
Calcium Sensor DREAM and Pollutant-Triggered Pancreatic Stress
Researchers are studying how certain pollutants might disrupt calcium signaling in the pancreas and affect insulin- and hormone-secreting cells, which could influence diabetes-related health.
-
Understanding how Latino caregivers engage with early autism services
This project looks at how Latino families engage with early intervention services for children with autism to improve access and quality of care.
-
Role of AnnexinA2 in HIV-1 and SARS-CoV-2 virus assembly
Scientists are studying how a protein called AnnexinA2 helps HIV-1 and SARS-CoV-2 viruses assemble inside cells, which could point to new ways to block these infections.
-
Aorta remodeling after endovascular repair and its long-term effects
This project looks at how the aorta changes after repair with endografts and what that means for people with type-B aortic dissection.
-
De Novo Synthesis of Collagen-Like Polymers for Biomedical Uses
A new method to make large, collagen-like polymers in the lab that could be used for safer, customizable medical materials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.