Understanding how cancer cells survive stress in their environment
Molecular Mechanisms Underlying Cell Survival During Endoplasmic Reticulum Stress
This study is looking at how cancer cells cope with tough conditions in their environment and trying to find ways to make them more sensitive to treatments, which could help develop better therapies for cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Long Beach NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project ID | NIH-10811665 on NIH RePORTER |
What this research studies
This research investigates how cancer cells manage stress from their environment, particularly focusing on a cellular process called endoplasmic reticulum (ER) stress. When cells experience this stress, they activate a protective response to survive, but if the stress continues, they may die. The study aims to uncover the molecular mechanisms that allow cancer cells to adapt and survive under these stressful conditions, which could lead to new cancer treatments. By examining specific pathways that promote cell survival, the research seeks to identify potential targets for therapies that could make cancer cells more vulnerable to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer who may benefit from new treatment strategies aimed at overcoming cancer cell resistance.
Not a fit: Patients with non-cancerous conditions or those whose cancer is already at an advanced stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the effectiveness of cancer treatments by targeting the survival mechanisms of cancer cells.
How similar studies have performed: Previous research has shown that targeting cellular stress responses can improve treatment outcomes in cancer, indicating that this approach has potential for success.
Where this research is happening
Long Beach, United States
- California State University Long Beach — Long Beach, United States (Active)
Researchers
- Principal investigator: Bhandari, Deepali — California State University Long Beach
- Study coordinator: Bhandari, Deepali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.