Understanding how cancer cells resist treatment with cisplatin
Systems Bioinformatics Core
This study is looking into why some head and neck cancer cells don't respond to cisplatin, a common chemotherapy drug, and aims to find ways to help make treatments more effective for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10917407 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms behind why some head and neck cancer cells become resistant to cisplatin, a common chemotherapy drug. By analyzing genomic, transcriptomic, and metabolomic data, the project aims to identify biomarkers that indicate resistance and develop strategies to prevent it. The research will utilize advanced data analysis techniques and integrate findings from various projects to create a comprehensive understanding of cisplatin response. Patients may benefit from insights that could lead to improved treatment options and personalized therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma (HNSCC) who are undergoing treatment with cisplatin.
Not a fit: Patients with cancers other than head and neck squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for patients with head and neck cancer who are resistant to cisplatin.
How similar studies have performed: Previous research has shown success in identifying biomarkers for drug resistance in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Coarfa, Cristian — University of Tx Md Anderson Can Ctr
- Study coordinator: Coarfa, Cristian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.