Understanding How Cancer Cells React to Treatments
Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell Level
This project aims to understand how cancer cells change and respond to different treatments, helping us find better ways to fight cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11175304 on NIH RePORTER |
What this research studies
We want to create detailed computer models of cancer cells to predict how they will behave when faced with treatments, genetic changes, or interactions with other cells in the body. Cancer cells are very adaptable and can change their behavior, making them hard to treat effectively. By building these models, we hope to uncover new weaknesses in cancer cells that are less likely to be overcome by their adaptive nature. This deeper understanding could lead to more effective and lasting therapies for aggressive cancers.
Who could benefit from this research
Good fit: This foundational research is relevant to all patients living with cancer, particularly those with aggressive forms that are difficult to treat.
Not a fit: Patients will not receive direct, immediate benefit from this basic science research, as it focuses on developing predictive models rather than direct patient intervention.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new, more effective treatments for aggressive cancers by predicting how they will respond to different therapies.
How similar studies have performed: This project builds upon prior research in cellular network modeling and aims for a significant advancement in predicting cancer cell behavior.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Califano, Andrea — Columbia University Health Sciences
- Study coordinator: Califano, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.